{"id":125,"date":"2025-09-12T05:09:52","date_gmt":"2025-09-12T05:09:52","guid":{"rendered":"https:\/\/jbecosmetics.com\/?post_type=product&p=125"},"modified":"2025-09-12T05:09:52","modified_gmt":"2025-09-12T05:09:52","slug":"tesofensine-500mcg-x-30-tablets","status":"publish","type":"product","link":"https:\/\/jbecosmetics.com\/index.php\/product\/tesofensine-500mcg-x-30-tablets\/","title":{"rendered":"Tesofensine (500mcg) x (30 tablets)"},"content":{"rendered":"

This product is prepared for\u00a0LABORATORY RESEARCH USE ONLY<\/strong>\u00a0and may not be used for other purposes.<\/p>\n

 <\/p>\n

\n

What is Tesofensine?<\/h3>\n

Tesofensine<\/strong>\u00a0is a triple reuptake inhibitor that influences the neurotransmitters\u00a0dopamine, serotonin, and noradrenaline<\/strong>. Initially developed by\u00a0NeuroSearch<\/strong>\u00a0for treating\u00a0Alzheimer\u2019s<\/strong>\u00a0and\u00a0Parkinson\u2019s diseases<\/strong>, researchers discovered significant\u00a0weight loss<\/strong>\u00a0as a side effect during clinical trials. This led to a shift in focus, and tesofensine is now being studied primarily for its potential role in\u00a0obesity treatment<\/strong>.<\/p>\n

\n

Mechanisms of Action<\/h3>\n
    \n
  • Appetite Suppression<\/strong>
    \nTesofensine primarily works by reducing appetite, which directly impacts caloric intake.<\/li>\n
  • Energy Metabolism Enhancement<\/strong>
    \nIt slightly increases energy expenditure, supporting weight management through dual-action mechanisms.<\/li>\n
  • Neurotransmitter Modulation<\/strong>
    \nTesofensine increases levels of dopamine, serotonin, and noradrenaline, contributing to its effects on neurological and metabolic disorders.<\/li>\n<\/ul>\n
    \n

    Research Focus Areas<\/h3>\n

    Tesofensine is being investigated for its potential applications in various fields, including:<\/p>\n

    1. Weight Loss<\/strong><\/h4>\n

    Tesofensine has been studied extensively for its potential to induce\u00a0significant weight loss<\/strong>.<\/p>\n

      \n
    • In a\u00a02008 study published in\u00a0The Lancet<\/em><\/strong>, patients treated with tesofensine achieved an\u00a0average weight loss of 12.8 kg<\/strong>\u00a0over 24 weeks with higher doses, almost\u00a0double<\/strong>\u00a0that of currently approved medications.<\/li>\n
    • Tesofensine\u2019s ability to\u00a0suppress appetite<\/strong>\u00a0and modestly\u00a0increase energy expenditure<\/strong>\u00a0highlights its dual-action potential for treating obesity.<\/li>\n
    • Phase II clinical trials further demonstrated its ability to induce\u00a0dose-dependent weight loss<\/strong>\u00a0with minimal impact on blood pressure at lower doses.<\/li>\n<\/ul>\n

      2. Neurological Disorders<\/strong><\/h4>\n

      Tesofensine has been explored for its neuroprotective properties in diseases like\u00a0Parkinson\u2019s<\/strong>\u00a0and\u00a0Alzheimer\u2019s<\/strong>:<\/p>\n

        \n
      • It enhances levels of dopamine, serotonin, and noradrenaline in the brain, potentially addressing deficits common in neurological disorders.<\/li>\n
      • Studies suggest tesofensine may\u00a0protect neuronal cells<\/strong>\u00a0from oxidative stress and neurotoxicity, which are hallmark features of neurodegenerative diseases.<\/li>\n
      • Research in animal models indicated\u00a0improvements in motor function<\/strong>\u00a0for Parkinson\u2019s disease by modulating dopaminergic systems.<\/li>\n<\/ul>\n

        3. Addiction Research<\/strong><\/h4>\n

        Tesofensine has shown potential in modulating the reward pathways associated with addictive behaviors:<\/p>\n

          \n
        • A 2013 study demonstrated its ability to influence appetite through\u00a0noradrenergic and dopaminergic pathways<\/strong>, which are also implicated in addiction mechanisms.<\/li>\n
        • These findings suggest that tesofensine may have applications in\u00a0alcohol addiction<\/strong>\u00a0and other substance dependencies.<\/li>\n<\/ul>\n

          4. Metabolic Disorders<\/strong><\/h4>\n

          The weight-loss properties of tesofensine could have implications for managing metabolic conditions such as:<\/p>\n

            \n
          • Diabetes<\/strong>: Tesofensine has been shown to improve\u00a0plasma insulin<\/strong>\u00a0and\u00a0HbA1c concentrations<\/strong>, critical markers for blood sugar control.<\/li>\n
          • Metabolic Syndrome<\/strong>: By reducing fat mass and weight, tesofensine may address obesity-related risk factors for this condition.<\/li>\n<\/ul>\n
            \n

            Tesofensine Research Data<\/h3>\n\n\n\n\n\n\n\n
            Dosage<\/strong><\/th>\nAverage Weight Loss (%)<\/strong>*<\/th>\n<\/tr>\n<\/thead>\n
            0.25 mg<\/strong><\/td>\n4.5%<\/td>\n<\/tr>\n
            0.5 mg<\/strong><\/td>\n9.2%<\/td>\n<\/tr>\n
            1.0 mg<\/strong><\/td>\n10.6%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

            *Weight loss compared to diet + placebo group.<\/p>\n

            \n

            Legal Disclaimer<\/h3>\n

            This product is sold as a\u00a0pure research compound<\/strong>\u00a0and is not intended for human consumption or use as a dietary supplement, drug, or treatment. It is provided solely for\u00a0laboratory research purposes<\/strong>\u00a0and must not be used for diagnostic or therapeutic purposes, in food, cosmetics, or any medical applications.<\/p>\n

            The statements on this website have not been evaluated by the\u00a0U.S. Food and Drug Administration (FDA)<\/strong>. This product is not intended to diagnose, treat, cure, or prevent any disease or medical condition. All products are for\u00a0research and development use only<\/strong>.<\/p>\n

            \n

            Important Safety Information<\/h3>\n
              \n
            • Keep this product out of the reach of children.<\/li>\n
            • Limited research is available on this material, and improper handling or use may pose risks or result in adverse effects.<\/li>\n
            • This product is sold solely as a raw material for research purposes, and its\u00a0purity and quality are attested exclusively for these purposes<\/strong>.<\/li>\n
            • It is intended for handling only by qualified researchers with the necessary knowledge and equipment to safely manage such materials.<\/li>\n<\/ul>\n

              By purchasing, you agree to indemnify\u00a0Molecular Solutions Peptides<\/strong>\u00a0against any adverse effects that may arise from improper handling or use of this product.<\/p>\n

              \n

              Educational Notice<\/h3>\n

              All information on this website is provided solely for\u00a0educational purposes<\/strong>. These products are not pharmaceuticals or medications. The\u00a0Food and Drug Administration (FDA)<\/strong>\u00a0has not approved them for the treatment, prevention, or cure of any disease, medical condition, or ailment.<\/p>\n","protected":false},"excerpt":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n\n
              Property<\/strong><\/th>\nDetails<\/strong><\/th>\n<\/tr>\n<\/thead>\n
              Name<\/strong><\/td>\nTesofensine<\/td>\n<\/tr>\n
              Quantity<\/strong><\/td>\n500mcg (30 Tablets)<\/td>\n<\/tr>\n
              Container<\/strong><\/td>\nPlastic Container<\/td>\n<\/tr>\n
              Presentation<\/strong><\/td>\nTablets<\/td>\n<\/tr>\n
              Molecular Formula<\/strong><\/td>\nC17H23Cl2NO<\/td>\n<\/tr>\n
              Molecular Weight<\/strong><\/td>\n328.3 g\/mol<\/td>\n<\/tr>\n
              PubChem CID<\/strong><\/td>\n11370864<\/td>\n<\/tr>\n
              Synonyms<\/strong><\/td>\nTesofensine, 195875-84-4, NS-2330, Tesofensine [INN], BLH9UKX9V1<\/td>\n<\/tr>\n
              Research Applications<\/strong><\/td>\nWeight Loss, Appetite Suppression, Obesity<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":62,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[20],"product_tag":[],"class_list":["post-125","product","type-product","status-publish","has-post-thumbnail","product_cat-obesity-reduction-glp-1-gip-fat-loss","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","sale","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/jbecosmetics.com\/index.php\/wp-json\/wp\/v2\/product\/125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jbecosmetics.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/jbecosmetics.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/jbecosmetics.com\/index.php\/wp-json\/wp\/v2\/comments?post=125"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jbecosmetics.com\/index.php\/wp-json\/wp\/v2\/media\/62"}],"wp:attachment":[{"href":"https:\/\/jbecosmetics.com\/index.php\/wp-json\/wp\/v2\/media?parent=125"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/jbecosmetics.com\/index.php\/wp-json\/wp\/v2\/product_brand?post=125"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/jbecosmetics.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=125"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/jbecosmetics.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}